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NOW Supplements, Vitamin B-6 (Pyridoxine HCl) 100 mg, Cardiovascular Health*, 250 Veg Capsules

4.7 4.7 out of 5 stars 5,280 ratings

Sustainability features

This product has sustainability features recognized by trusted certifications.

Packaging efficiency

Reduced air and/or water in the product or packaging for more efficient transportation.

As certified by
Compact by Design (Amazon-developed Certification) Compact by Design (Amazon-developed Certification)

Compact by Design identifies products that, while they may not always look very different, have a more efficient design. By reducing water and/or air in the product or packaging, these become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

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Climate Pledge Friendly

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250 Count (Pack of 1)

Purchase options and add-ons

Brand NOW
Item Form Capsule
Primary Supplement Type Vitamin B6
Diet Type Vegetarian
Flavor Unflavored

About this item

  • Supports Healthy Homocysteine Metabolism*
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • Important for Nervous System Function*
  • Cardiovascular Health*
  • GMP Quality Assured: NOW closely adheres to both mandatory U.S. FDA Current Good Manufacturing Practices (CGMP) regulations and voluntary Natural Products Association (NPA) Good Manufacturing Practices (GMP) regulations. Good manufacturing practices ensure compliance with sanitation, processing, documentation, and testing requirements that are designed to promote consistent, highly reproducible product quality and safety.
  • Packaged in the USA by a family owned and operated company since 1968
  • During the summer months products may arrive warm but Amazon stores and ships products in accordance with manufacturers' recommendations, when provided.

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Sustainability features

Sustainability features

This product has sustainability features recognized by trusted certifications.

Packaging efficiency

Reduced air and/or water in the product or packaging for more efficient transportation.

As certified by
Compact by Design (Amazon-developed Certification) Compact by Design (Amazon-developed Certification)

Compact by Design identifies products that, while they may not always look very different, have a more efficient design. By reducing water and/or air in the product or packaging, these become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

Learn more about this certification

Part of
Sustainability features
Climate Pledge Friendly

Focus on sustainability

Compact by design from Climate pledge friendly. Certified by Amazon.

Small changes in product size & weight lead to lower carbon emissions.

We created Compact by Design to identify products that, while they may not always look very different, have a more efficient design. With the removal of excess air and water, products require less packaging and become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

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Waterless technology

Product Description

Product Description

Vitamin B-6 is a cofactor in numerous enzymatic reactions and is required for the metabolism of fats, carbohydrates, and proteins.* It facilitates the conversion of amino acids from one to another as needed, and is necessary for normal synthesis of hemoglobin, as well as for normal function and production of red blood cells.* B-6 plays an important role in regulating homocysteine metabolism in the body.* Homocysteine, a by-product of the methionine cycle, is known to be destructive to bodily tissues, especially vascular structures. B-6 is also critical for the maintenance of a healthy nervous system.*

Brand Story

By NOW Foods

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 7.48 x 7.48 x 11.81 inches; 5.6 ounces
  • Item model number ‏ : ‎ 0458
  • Date First Available ‏ : ‎ January 8, 2004
  • Manufacturer ‏ : ‎ NOW Sports - Nutrition and Wellness
  • ASIN ‏ : ‎ B005P0XRK0
  • Country of Origin ‏ : ‎ USA
  • Customer Reviews:
    4.7 4.7 out of 5 stars 5,280 ratings

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NOW Supplements, Vitamin B-6 (Pyridoxine HCl) 100 mg, Cardiovascular Health*, 250 Veg Capsules
NOW Supplements, Vitamin B-6 (Pyridoxine HCl) 100 mg, Cardiovascular Health*, 250 Veg Capsules
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Price-39% $12.24
List:$19.99
-15% $9.99
List:$11.75
$9.74-25% $11.95
List:$15.95
$10.99
Price Per Unit$0.05 / Count$0.02 / Count$9.74 / Count$0.05 / Count$0.11 / Count
Delivery
Get it as soon as Monday, Apr 1
Get it as soon as Monday, Apr 1
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Customer Ratings
Value for money
4.7
4.9
4.6
4.6
4.7
Easy to swallow
4.7
4.8
4.5
4.6
4.7
Flavor
4.6
4.6
4.6
4.5
4.5
Sold By
Amazon.com
Carlyle
VitaCare
eSupplements
Amazon.com
primary supplement
Vitamin B6
Vitamin B6
Vitamin-b
Vitamin B6
Vitamin B6
form
Capsule
Tablet
Tablet
Capsule
Tablet
unit count
250
500
1
240
100
flavor
Unflavored
Unflavored
100 mg
Unflavored
Unflavored
target gender
unisex
unisex
unisex
unisex
unisex
weight
0.35 pounds
100 milligrams
100 milligrams
2.12 ounces
specific uses
Heart, Nerve
Nerve
Energy
Energy Metabolism Support
serving suggestion
1 capsule
1 tablet
1 capsule
Adults, take 1 tablet daily with water and a meal.

Important information

Safety Information

As with any dietary or herbal supplement, you should advise your health care practitioner of the use of this product. If you are nursing, pregnant, or considering pregnancy, you should consult your health care practitioner prior to using this product. Keep out of reach of children.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

Ingredients

Rice Flour and Gelatin (capsule)

Directions

As a dietary supplement, take 1 capsule daily, preferably with meals.

Legal Disclaimer

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Looking for specific info?

Customer reviews

4.7 out of 5 stars
4.7 out of 5
5,280 global ratings

Customers say

Customers like the value, performance, and effect on hormones of the vitamin. They mention that it works great, is agreeable to their system, and produces results. Some are happy with the quality, and ease of swallowing. Opinions are mixed on size and pain relief.

AI-generated from the text of customer reviews

84 customers mention84 positive0 negative

Customers are satisfied with the quality of the vitamin. They mention that it is a great product, easy to take, and has good energy.

"...They definitely help and I like the quality, usually, of NOW products. This one has continually failed time and time again...." Read more

"Good value. Easy to swallow capsule. Good quality." Read more

"...Great product, affordable!" Read more

"...This is a quality product, but it is difficult to say whether or not it has helped with my carpal tunnel..." Read more

77 customers mention77 positive0 negative

Customers appreciate the value of the vitamins. They mention that it is easy to swallow, has good quality, and is good value for the bottle ordered. Some say that the company seems sincere and sells decent products.

"I use these supplements for my health and appreciate the price." Read more

"...and comparably the price is very economical and it does produce results. How can you tell?..." Read more

"Good price and I like the brand" Read more

"Cost per pill is awesome" Read more

72 customers mention68 positive4 negative

Customers are satisfied with the effect of the vitamins on hormones. They mention that it helps with energy levels and overall mood, helps with metabolism, and is good for the brain. Some say that it's good for keeping them calm and that increased serotonin helps eliminate migraines. Overall, customers are happy with the effects and recommend the product.

"Great supplements that you can trust from this brand. Easy to swallow and easy on stomach. Recommend" Read more

"It’s seems to help with me not being restless. Some needed relief." Read more

"...I also noticed that it has cleared up my acne! I normally break out along my jawline and neck and cysts on cheeks and I have had no new cysts!..." Read more

"...It's a water soluble vitamin so I am not worried about an overdose. What you don't need, your body gets rid of in urine." Read more

38 customers mention34 positive4 negative

Customers like the performance of the vitamin. They mention that it works well for helping patients on seizure meds, reduces headaches, and is agreeable to their system. Some say that it has helped reduce tendonitis pain and balance their blood levels.

"...and comparably the price is very economical and it does produce results. How can you tell?..." Read more

"It’s fine. Hope it’s effective. Good value. No flavor. Easy to swallow." Read more

"...We are seeing unbelievably positive results!..." Read more

"...It works quite well. Taking only 50mg a day could take two months before the symptoms disappear...." Read more

35 customers mention32 positive3 negative

Customers find the vitamin easy to swallow. They say it's small, easy to digest, and easy on their stomach.

"Great supplements that you can trust from this brand. Easy to swallow and easy on stomach. Recommend" Read more

"I like capsules far better than chalky tablets! Easier to swallow. How?..." Read more

"...They are not large capsules and are easy to swallow with no taste." Read more

"It’s fine. Hope it’s effective. Good value. No flavor. Easy to swallow." Read more

23 customers mention14 positive9 negative

Customers are mixed about the pain relief. Some mention that it relieves carpal tunnel tingling, and reduces headaches. However, others say that it causes severe nerve pain throughout the body.

"...Haven’t had an issue getting off anti depressants and l feel great. I take two a day and only use this brand for all my supplemental needs. Amazing!" Read more

"...problems, body aches & very sore joints, rashes, itching, loss of s3xual sensation, and a whole host of other symptoms getting progressively worse..." Read more

"These seem to help a bit with my carpal tunnel syndrome...." Read more

"...I read about B6 helping... well.... Two bottles later I have almost no symptoms... I wouldn't say cured... But it's good enough to not bother me..." Read more

16 customers mention11 positive5 negative

Customers are mixed about the size of the vitamin. Some mention that they are not large capsules and easy to swallow with no taste, while others say that it is a bit larger than they would like and sometimes hard to swallow.

"...They are not large capsules and are easy to swallow with no taste." Read more

"Product is easy to take and no flavor which is nice. The capsules are not overly large which makes it easier for those who usually have an issue..." Read more

"Larger capsule, has a tendency to stick going down. Will not buy again." Read more

"As expected. Good price for amount. Small and easy to swallow." Read more

13 customers mention8 positive5 negative

Customers have mixed opinions about the taste of the vitamin. Some mention it has no taste, while others say it has a terrible taste and makes them hungry.

"It’s fine. Hope it’s effective. Good value. No flavor. Easy to swallow." Read more

"...However, I ended up burping up a nasty after taste for several hours each day...." Read more

"Product is easy to take and no flavor which is nice...." Read more

"It has no flavor. Yiu receive a generous amount in the bottle. You only need one a day so it should last you for quite a while...." Read more

NOW is great brand - BUT taking 100mg B6 w/o confirmed deficiency gave me nerve damage.
5 Stars
NOW is great brand - BUT taking 100mg B6 w/o confirmed deficiency gave me nerve damage.
I like NOW as a brand, hence the 5 stars. However, it’s REALLY important before/while taking this you have your doctor test your B6 levels (mine is attached--3x upper limit after I hadn't taken it for a month!).We’ve always been told since Bs are water-soluble you can’t take too much because you pee out what you don’t need. Not necessarily true with B6. And even low levels of B6 can build up to toxic levels in your body and cause debilitating and possibly permanent health issues. I know it sounds wacky--but I’ve got a legit link below for you to read. As with everything, do more of your own research and draw your own conclusions. I’m simply letting folks know just in case you start experiencing the same issues as me (and my uncle).The RDA for B6 is 1.5-2mg depending on age/sex. This 100mg supplement is 5882% of the daily dose. The maximum allowance according to the FDA is 100mg/day in the US, however, in other countries (Europe, Australia) they consider B6 dangerous as low as 10mg a day. My doctors always praised me for taking my Bs and never asked how many milligrams I was taking. They also never tested my vitamin levels. That may be the case with you too (if so, keep reading).I’ve had neuropathy in my legs (that feels like water retention with no visible swelling), chronic fatigue, massive brain fog, bladder problems, body aches & very sore joints, rashes, itching, loss of s3xual sensation, and a whole host of other symptoms getting progressively worse for SEVENTEEN YEARS. As these mystery symptoms progressed, I and my doctors wondered if I had some sort of auto-immune issue. We also explained away some symptoms with age/arthritis/out of shape/perimenopause/not ENOUGH vitamin B12 & 6/edema/drink more water/get more exercise/etc.I started taking 100mg of B6 in 2019 in addition to the daily B6 I had been getting for 15ish years from a high protein diet, multivitamins, B-complex, fortified protein shakes & bars, vitamin water, etc. (FYI - B6 is fortified in so many foods. Between that and what we get from our diets, especially if we eat meat--we’re already likely getting enough/too much. Energy drinks often have a lot too).By this year (2021) my symptoms went off the rails. For the 15+ years prior they had been annoying and getting progressively worse. But in early 2021 they became intolerable & completely debilitating. It was HORRIBLE, I could not function. I wondered if I was dying, had early signs of chronic disease, cancer, etc. I honestly thought the doctor would find I had MS. All I knew for sure was something was VERY WRONG.Through months of HELL I came across something about B6 toxicity. I had stopped taking all supplements 4 weeks before this when I started an elimination diet to see if I could figure out why my symptoms were happening. I was just starting to feel MUCH better when I learned B6 toxicity was a thing and fit my symptoms to a T. I got a B6 lab test and my blood tested three times the upper limit for B6 (attached). This was after NOT taking B6 for a month and feeling so much better--I can’t imagine how high my B6 blood levels were at my worst. From what I understand when stopping B6 your blood levels drop fast (although it's stored in your muscles and tissue for years). Detectable blood levels typically cut in half after about 2 weeks. I may have been 6-7x the upper limit or more!I was taking this NOW B6 supplement plus a regular drugstore B-complex, and getting B6 from natural food and fortified foods. All together 110mg of B6 a day tops. My nerve damage from that (and years of much lower levels--probably 5-25 mg a day 2004-2019) may be irreversible. Even if I can reverse it, it will take at least a year or two for the excess B6 to release from storage in my muscles, tissues, etc. During that time I’ll have to carefully monitor my B6 intake and still go through periods of debilitating symptoms.B6 toxicity is not uncommon either. It also doesn’t only happen to people who have been taking it for years like me. It IS often missed/misdiagnosed tho because docs in the US typically don’t routinely test vitamin levels. B6 toxicity also has very similar symptoms to B12 deficiency so we’re accustomed to just guessing & sometimes throwing the wrong vitamin at our problem. Vitamin supplementation has also skyrocketed over the pandemic too so this is affecting more people right now.Emery Pharma who was behind the Zantac recall just petitioned the FDA on 9/20/21 to regulate B6 supplements. Their stance is 100mg is way too much for someone who isn’t confirmed deficient by a doc/blood test and can be very dangerous. This is the 19 page FDA petition & it has very insightful info about mega doses of B6 (again, a 100mg pill is 5882% of the RDA). I don't think I can put weblinks in a review so the P D F is called B6-Citizen-Petition-Final and it's on the Emery Pharma dot comm websiteMy elderly uncle also started taking 100mg of B6 daily because his doctor said it would be good for him. Doc never tested his levels. He took it for a few years. He went from a very active/healthy old man to very suddenly unable to walk, control his toileting, horrible vertigo, and other symptoms that are all classic B6 toxicity issues. His health rapidly declined for 1.5 years up until his death in 2019. There’s no way to know for sure if the B6 was responsible for some/all of his issues but based on everything else--it’s very possible it was at minimum partially a factor.I had NO IDEA the RDA for B6 was so low, 100mg supplements were too high for someone without a verified deficiency, and it could cause all of these health problems. I also had no idea that “you pee out B vitamins your body doesn’t need” isn’t true with B6.Before you supplement with high doses of B6 like this I URGE YOU get your vitamin levels assessed via blood test. And if you’ve been taking this and have mystery symptoms you chalk up to age/changing bodies/maybe you’re getting leg cramps because your electrolytes are off/you have these symptoms so you must need MORE B vitamins/etc. Look into too much B6 being the culprit.I’m not demonizing B6 or NOW (again, I like the brand). I also understand some people legit need high levels of B6 like this. What I am saying is many of us THINK we can tolerate these high levels based on a guess & if we’re wrong it's no big deal because B vitamins are “harmless.” Nope--in reality, if we guess wrong it could have very serious health consequences. Please consult your doc & do some of your own research on B6 before popping 100mg every day.
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5.0 out of 5 stars NOW is great brand - BUT taking 100mg B6 w/o confirmed deficiency gave me nerve damage.
Reviewed in the United States on October 8, 2021
I like NOW as a brand, hence the 5 stars. However, it’s REALLY important before/while taking this you have your doctor test your B6 levels (mine is attached--3x upper limit after I hadn't taken it for a month!).

We’ve always been told since Bs are water-soluble you can’t take too much because you pee out what you don’t need. Not necessarily true with B6. And even low levels of B6 can build up to toxic levels in your body and cause debilitating and possibly permanent health issues. I know it sounds wacky--but I’ve got a legit link below for you to read. As with everything, do more of your own research and draw your own conclusions. I’m simply letting folks know just in case you start experiencing the same issues as me (and my uncle).

The RDA for B6 is 1.5-2mg depending on age/sex. This 100mg supplement is 5882% of the daily dose. The maximum allowance according to the FDA is 100mg/day in the US, however, in other countries (Europe, Australia) they consider B6 dangerous as low as 10mg a day. My doctors always praised me for taking my Bs and never asked how many milligrams I was taking. They also never tested my vitamin levels. That may be the case with you too (if so, keep reading).

I’ve had neuropathy in my legs (that feels like water retention with no visible swelling), chronic fatigue, massive brain fog, bladder problems, body aches & very sore joints, rashes, itching, loss of s3xual sensation, and a whole host of other symptoms getting progressively worse for SEVENTEEN YEARS. As these mystery symptoms progressed, I and my doctors wondered if I had some sort of auto-immune issue. We also explained away some symptoms with age/arthritis/out of shape/perimenopause/not ENOUGH vitamin B12 & 6/edema/drink more water/get more exercise/etc.

I started taking 100mg of B6 in 2019 in addition to the daily B6 I had been getting for 15ish years from a high protein diet, multivitamins, B-complex, fortified protein shakes & bars, vitamin water, etc. (FYI - B6 is fortified in so many foods. Between that and what we get from our diets, especially if we eat meat--we’re already likely getting enough/too much. Energy drinks often have a lot too).

By this year (2021) my symptoms went off the rails. For the 15+ years prior they had been annoying and getting progressively worse. But in early 2021 they became intolerable & completely debilitating. It was HORRIBLE, I could not function. I wondered if I was dying, had early signs of chronic disease, cancer, etc. I honestly thought the doctor would find I had MS. All I knew for sure was something was VERY WRONG.

Through months of HELL I came across something about B6 toxicity. I had stopped taking all supplements 4 weeks before this when I started an elimination diet to see if I could figure out why my symptoms were happening. I was just starting to feel MUCH better when I learned B6 toxicity was a thing and fit my symptoms to a T. I got a B6 lab test and my blood tested three times the upper limit for B6 (attached). This was after NOT taking B6 for a month and feeling so much better--I can’t imagine how high my B6 blood levels were at my worst. From what I understand when stopping B6 your blood levels drop fast (although it's stored in your muscles and tissue for years). Detectable blood levels typically cut in half after about 2 weeks. I may have been 6-7x the upper limit or more!

I was taking this NOW B6 supplement plus a regular drugstore B-complex, and getting B6 from natural food and fortified foods. All together 110mg of B6 a day tops. My nerve damage from that (and years of much lower levels--probably 5-25 mg a day 2004-2019) may be irreversible. Even if I can reverse it, it will take at least a year or two for the excess B6 to release from storage in my muscles, tissues, etc. During that time I’ll have to carefully monitor my B6 intake and still go through periods of debilitating symptoms.

B6 toxicity is not uncommon either. It also doesn’t only happen to people who have been taking it for years like me. It IS often missed/misdiagnosed tho because docs in the US typically don’t routinely test vitamin levels. B6 toxicity also has very similar symptoms to B12 deficiency so we’re accustomed to just guessing & sometimes throwing the wrong vitamin at our problem. Vitamin supplementation has also skyrocketed over the pandemic too so this is affecting more people right now.

Emery Pharma who was behind the Zantac recall just petitioned the FDA on 9/20/21 to regulate B6 supplements. Their stance is 100mg is way too much for someone who isn’t confirmed deficient by a doc/blood test and can be very dangerous. This is the 19 page FDA petition & it has very insightful info about mega doses of B6 (again, a 100mg pill is 5882% of the RDA). I don't think I can put weblinks in a review so the P D F is called B6-Citizen-Petition-Final and it's on the Emery Pharma dot comm website

My elderly uncle also started taking 100mg of B6 daily because his doctor said it would be good for him. Doc never tested his levels. He took it for a few years. He went from a very active/healthy old man to very suddenly unable to walk, control his toileting, horrible vertigo, and other symptoms that are all classic B6 toxicity issues. His health rapidly declined for 1.5 years up until his death in 2019. There’s no way to know for sure if the B6 was responsible for some/all of his issues but based on everything else--it’s very possible it was at minimum partially a factor.

I had NO IDEA the RDA for B6 was so low, 100mg supplements were too high for someone without a verified deficiency, and it could cause all of these health problems. I also had no idea that “you pee out B vitamins your body doesn’t need” isn’t true with B6.

Before you supplement with high doses of B6 like this I URGE YOU get your vitamin levels assessed via blood test. And if you’ve been taking this and have mystery symptoms you chalk up to age/changing bodies/maybe you’re getting leg cramps because your electrolytes are off/you have these symptoms so you must need MORE B vitamins/etc. Look into too much B6 being the culprit.

I’m not demonizing B6 or NOW (again, I like the brand). I also understand some people legit need high levels of B6 like this. What I am saying is many of us THINK we can tolerate these high levels based on a guess & if we’re wrong it's no big deal because B vitamins are “harmless.” Nope--in reality, if we guess wrong it could have very serious health consequences. Please consult your doc & do some of your own research on B6 before popping 100mg every day.
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